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A review of Veterinary Research in Epigenetics

Rebecca Zaremba, Ross University

Cases/Abstracts, Honorable Mention           


 For many years, millions[ACL1]  of healthy women and their families have suffered from miscarriage, which is openly defined as the loss of a fetus under 20 weeks of age (The March of Dimes). The trauma of miscarriage often impacts entire families, from expectant mothers and fathers to siblings, grandparents, aunts and uncles. Many factors can cause miscarriage, and most of these are poorly understood. It is important to determine etiologies of miscarriage and it is also equally important to be able to understand that these tragedies do not disappear after the loss of the baby. Fortunately, the veterinary field has helped immensely in determining specific point mutations which are thought to be responsible for such tragedies in humans.

            One of the long-term goals of the Lossie lab is to understand the genetic and epigenetic causes of miscarriage. In an effort to understand these mechanisms, we have characterized two lethal mutations in mice known as l11Jus1 (L1) and l11Jus4 (L4). L1 and L4 are two separate mutations in a gene called Notchless (Nle1), which is a component found downstream to the Notch pathway (Baumgarner et al. 2007). These two mutant lines survive through the blastocyst stage (Figure 1) and are able to successfully implant into the uterus. However, neither L1 nor L4 survive past implantation; they arrest prior to gastrulation, which eventually leads to an immature body.

Figure 1. Implantation

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Meghan Shuman, Western University

Creative Corner, Entry



Partners for Healthy Pets - August Newsletter

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Reflections on Second Year

Christine Mallo, University of Illinois

Life as a Vet Student, Entry


Second year, oh second year. As those of us enrolled in veterinary school understand, the type of graduate problem we have aspired our whole lives to be a part of comes as a challenge. There are up and downs, and then they are repeated over and over. Sometimes it feels like there isn’t going to be a break, which is exactly how the second year of school felt for me. It was a challenge, a struggle, and down-right hard, but at the end of the day, I can honestly say that this year has made me not only a stronger student, but a more appreciative individual as well.

Most students would agree that first year of school is the most shocking, as the format of the curriculum is new for all and adjustments must be made quickly to keep up. For me, I went into first year expecting the absolute hardest year of my life, and while it was difficult, I kept my head high and my mind focused and was proud of the grades I received.

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Goat On A Branch

Brooke Warner, UC Davis

Creative Corner, Entry

 Sterling silver pin modeled after Ms. Warner's mother's Boer goat

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